Thursday, February 18, 2010

Diabetes (Clinical Test)

For Clinical test cases of diabetes using stem-cell treatment, Check out this SlideShare Presentation:

Wednesday, February 17, 2010

Osteoarthritis - Stem Cell Treatment


How many osteoarthritis in knees have been treated in your center?
 
9 cases have been treated for the past three years
 
What is the percentage of improvement?
 
All patients have seen great improvement and enjoy much more comfortable life.
But we should not say it is cured 
 
Where do you see improvement (clinical and / or x-ray)?
 
Patient himself know improvement and clinical and X-ray will show improvement
but it requires time to see improvement
 
What type of stem cell? This gentleman is interested in adipose tissue stem cells.
 
One time of local injection to knee joints via puncture. Adipose tissue derived stem cell
is OK for this treatment.
 
But if the kneed joint is used after stem cell implant, the cell cultivation is delayed or
disturbed and the patient should have plaster caster for 3-4 months.
 
However, after 3-4 months of plaster caster, around 6 months of rehabilitation would be needed 
because patient cannot use leg for 4 months
 
How many treatments does a patient need based on your clinical experience?
 
One time of treatment but with 4 months of plaster caster and then 6months of rehabilitation.
 
How much is it for the first treatment? :
 
US$10,000.00 for 50 Millions of adipose stem cells.
But depending upon seriousness of Osteoarthritis after checking,
patient would need over 100 millions of adipose tissue derived stem cells.
 
100Million stem cells costs US$17000 including liposuction, cultivation, operation
for local injection to knee joints. If patient want to store the stem cells for 10 years,
US$3000 will be needed more.
 
Will the treatment make the osteoarthritis worse?
 
It cannot be happened in stem cell treatment
 
Julia, please check if this patient still wants treatment or not
and if you need Medical valuation Report I will send you

Monday, February 15, 2010

Stem Cell Treatments for Diabetes

Can prevent 100% diabetes complications but diabetes therapy cannot assure complete cure (Reason: difficult to control patient food challenges) All remaining diabetes complications can be treated except for Retinal.


  • Diabetes type 1: HLA type structure is changed and destroys itself (checking while 6 months therapy is made.   
  • Diabetes type 2: Curable but very often checking to see any change. (guaranty of complete treatment is not possible due to patient food control failure)

Contact us for more questions: contact@bbnworld.com

FAQ regarding Stem Cell Treatments


Q. What are stem cells?
Ans. Stem cells are undifferentiated cells that have the ability to self-renew and differentiate into specialized cell types. These properties give stem cells regenerative characteristics that research is showing can repair damaged tissue.

Q. What are the different types of Stem Cells?
Ans. Stem cells can be categorized on various bases:
On the basis of Potency level:
Potency specifies the differentiation potential (the potential to differentiate into different cell types) of the stem cell.
  • Totipotent stem cells are produced from the fusion of an egg and sperm cell. Cells produced by the first few divisions of the fertilized egg are also totipotent. These cells can differentiate into embryonic and extraembryonic cell types.
  • Pluripotent stem cells are the descendants of totipotent cells and can differentiate into cells derived from any of the three germ layers
  • Multipotent stem cells can produce only cells of a closely related family of cells (e.g. hematopoietic stem cells differentiate into red blood cells, white blood cells, platelets, etc.).
  • Unipotent cells can produce only one cell type.

    On the basis of source:
  • Embryonic Stem cells: cells derived from the inner cell mass (ICM) of a blastocyst where a blastocyst is an early stage embryo-approximately four to five days old in humans and consisting of 50-150 cells. ES cells are pluripotent and can develop into each of the more than 200 cell types of the adult body when given sufficient and necessary stimulation for a specific cell type.
  • Adult stem cells: any cell which is found in a developed organism that has two properties: the ability to divide and create another cell like itself and also divide and create a cell more differentiated than itself. Most adult stem cells are multipotent in nature
Q. Why to prefer Adult stem cells?
Ans. Adult stem cells are safer having low proliferation rate and no ethical issues when compared to embryonic stem cells; therefore, exploring the possibility of using adult stem cells for cell-based therapies has become a very active area of investigation by researchers.

Q. Why an Autologous Stem Cell Transplant?
Ans. Many factors are considered when selecting an autologous or an allogeneic stem cell transplant. In general, an autologous stem cell transplant is safer and simpler than an allogeneic stem cell transplant. Since the donor and the recipient are the same (auto = you), no immunological differences exist. These new stem cells will not attack your body.

Q. What are the scientific bases of the stem cell therapy in Spinal Cord Injury?
Ans. The stem cells secrete neurotrophic factors when injected in the area of damage in the spinal cord. These neurotrophic factors help neurons and vessels to grow, thus helping repair the damage.

Q. What tests are required to be done before stem cell transplant?
Ans. Pre-transplant testing includes infectious disease blood tests, complete pulmonary function tests, cardiac ultrasound for left ventricular ejection fraction, liver and renal function blood tests and confirmatory HLA tissue typing and blood typing.

Q. What are the risks associated with adult stem cell therapy?
Ans. Usually autologous (from the patient's own cells) stem cell therapy is free of adverse affects like immunogenic rejection risk as in case of allogenic transplant. However, all surgery bears certain risks, from the anesthetic, infection, temporary discomfort, bleeding or wound healing problems. In very rare cases, transient epileptic seizures could occur. The benefits and possible side-effects vary from one disease to the next and between individuals. This should be discussed in detail with the transplant specialist involved in your case.

Q. What happens after Stem Cell Transplant?
Ans. Following an autologous stem cell transplant, most patients are back to work and feeling their old self again after 8-12 weeks. At times energy may still be low, appetite may vary, and emotionally patients may feel up and down.
Following an allogeneic stem cell transplant, most patients recover slowly. The mind tends to recover more rapidly than the body, and patients often become impatient with their progress. Before you leave the hospital, the nursing staff will discuss with you the routines of outpatient care. You will receive written information, and should ask about any aspect of which you feel uncertain. Discharge does not mean that the process is over. Very frequent hospital visits are necessary, initially probably two or three times a week. During such visits, infusions of drugs, fluids and electrolytes, and transfusion of blood products may be needed. At home, you will continue to take many medications. Among these are cyclosporine or prograf, antibiotics, magnesium, and vitamins. Complications are frequent, and may lead to readmission to the transplant unit. Patients will slowly start feeling better and complications become less frequent. Your medication will be reduced, and your visits less frequent. You may be able to go back to work 6 months after transplant, but if complications occur, 12 months is not uncommon.

Q. Could the injected stem cells develop into tumors?
Ans. There is the risk that stem cells not only support the regeneration of diseased somatic cells but also the increase of tumor cells. This risk is greater with the fast-growing embryonic stem cells than with adult stem cells, especially if embryonic stem cells are injected without prior differentiation. Animal testing has not yet found any cancer-causing potential in adult stem cells.
Q. What are the general benefits of Stem Cell Therapy?
Ans.
  • Restored activity of impaired and damaged internal organs and tissues.
  • Normalized production of red and white blood cells and improved immune function.
  • Improved Appetite.
  • Various effects leading to improved fitness, including increased feelings of energy, vigor and inner strength; improved mobility, coordination, strength and endurance; and increased desire for physical activity.
  • Improved mental capacity, concentration and ability to maintain attention; increased clarity of thinking, speech and memory.
  • Improved psychological state, including elevated mood and positive attitude; decreased irritability, sleepiness and apathy.
  • Improved sleeping pattern, with decreased insomnia and other sleep disturbances, and feelings of being refreshed upon awakening.
Q. What are the limitations of stem cell transplant?
  • With increasing age, there is a decrease in stem cell's viability and their ability to divide. 
  • Also in the older age, the capacity of body to support the therapy (or stem cell differentiation) decreases. 
  • Success of therapy also depend on the extent and time of the injury.
Hence, success of the therapy varies individual to individual.

Thursday, August 6, 2009